Seattle, Washington (206)744-3576 or 1-800-374-3267
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Faculty





Harborview Medical Center

Medical Director



John W. Miller, M.D., Ph.D. Medical Director, Neurologist
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John W. Miller, M.D., Ph.D. joined the Regional Epilepsy Center at Harborview as medical director in the spring of 1999. In addition to his duties as medical director of the Regional Epilepsy Center, he also serves as Professor of Neurology at the University of Washington School of Medicine. Prior to this appointment, he was the medical director of the Epilepsy Center at Barnes-Jewish Hospital in St. Louis. Dr. Miller completed his medical studies at the University of Illinois in Chicago in 1977 and earned a Ph.D. in anatomy there in 1981. He did his neurology residency and completed a fellowship in electroencephalography (EEG) and epilepsy at the Mayo Clinic in Rochester, MN, and another fellowship in neuropharmacology and epilepsy at Washington University in St. Louis. Dr. Miller has specialized in the treatment of epilepsy since 1985. He is board-certified in neurology with an added qualification in clinical neurophysiology and is also certified by the American Board of Clinical Neurophysiology. He is on the editorial board of Epilepsy Currents, is a member of the Epilepsy and Employment Task Force, and is part of the Continuing Medical Education Committee of the American Epilepsy Society. He has been elected to the American Neurological Association and voted one of the Best Doctors in America.
Location
Regional Epilepsy Center
4th Floor

Maleng Building
Harborview Medical Center
325 9th Avenue
Seattle, WA 98104
Selected Publications
  • Hakimian S, Kershenovich A, Miller JW, Ojemann JG, Hebb AO, D'Ambrosio R, Ojemann GA "Long-term outcome of extratemporal resection in posttraumatic epilepsy." Neurosurgical focus 2012 Mar; 32; 3; E10

  • Williamson DJ, Holsman M, Chaytor N, Miller JW, Drane DL "Abuse, not financial incentive, predicts non-credible cognitive performance in patients with psychogenic non-epileptic seizures." The Clinical neuropsychologist 2012 May; 26; 4; 588-98

  • Chaytor N, Ciechanowski P, Miller JW, Fraser R, Russo J, Unutzer J, Gilliam F "Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy." Epilepsy & behavior : E&B 2011 Mar; 20; 3; 545-9

  • Fraser RT, Johnson EK, Miller JW, Temkin N, Barber J, Caylor L, Ciechanowski P, Chaytor N "Managing epilepsy well: self-management needs assessment." Epilepsy & behavior : E&B 2011 Feb; 20; 2; 291-8

  • Miller JW, Cole AJ "Is it necessary to define the ictal onset zone with EEG prior to performing resective epilepsy surgery?" Epilepsy & behavior : E&B 2011 Feb; 20; 2; 178-81

  • Hakimian S, Miller JW "The genetics of antiepileptic drug-induced skin reactions." Clinical pharmacology and therapeutics 2011 Jun; 89; 6; 908-10

  • Miller JW "Teasing out the anatomy of mesial temporal lobe epilepsy." Epilepsy currents / American Epilepsy Society 2011 Sep; 11; 5; 145-6

  • Miller JW "Stopping seizures with carbon dioxide." Epilepsy currents / American Epilepsy Society 2011 Jul; 11; 4; 114-5

  • Miller JW "How dangerous is epilepsy?" Epilepsy currents / American Epilepsy Society 2011 May; 11; 3; 84-5

  • D'Ambrosio R, Miller JW "What is an epileptic seizure? Unifying definitions in clinical practice and animal research to develop novel treatments." Epilepsy currents / American Epilepsy Society 2010 May; 10; 3; 61-6

  • Holmes MD, Tucker DM, Quiring JM, Hakimian S, Miller JW, Ojemann JG "Comparing noninvasive dense array and intracranial electroencephalography for localization of seizures." Neurosurgery 2010 Feb; 66; 2; 354-62

  • D'Ambrosio R, Miller JW "Point." Epilepsy currents / American Epilepsy Society 2010 Jul; 10; 4; 90

  • Miller JW "Are generalized tonic-clonic seizures really "generalized"?" Epilepsy currents / American Epilepsy Society 2010 Jul; 10; 4; 80-1

  • Miller JW "Searching for the lesion in "MRI-normal" neocortical epilepsy--plumb the depths!" Epilepsy currents / American Epilepsy Society 2009 Nov-Dec ; 9; 6; 160-1

  • Miller JW "Systemic cooling to treat status epilepticus: an old idea becomes a hot topic." Epilepsy currents / American Epilepsy Society 2009 May-Jun ; 9; 3; 67-9

  • Drane DL, Ojemann GA, Ojemann JG, Aylward E, Silbergeld DL, Miller JW, Tranel D "Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization." Cortex; a journal devoted to the study of the nervous system and behavior 2009 May; 45; 5; 630-40

  • Kim W, Miller JW, Ojemann JG, Miller KJ "Ictal localization by invasive recording of infraslow activity with DC-coupled amplifiers." Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2009 Jun; 26; 3; 135-44

  • Thompson AW, Miller JW, Katon W, Chaytor N, Ciechanowski P "Sociodemographic and clinical factors associated with depression in epilepsy." Epilepsy & behavior : E&B 2009 Apr; 14; 4; 655-60

  • Anderson GD, Temkin NR, Dikmen SS, Diaz-Arrastia R, Machamer JE, Farhrenbruch C, Miller JW, Sadrzadeh SM "Haptoglobin phenotype and apolipoprotein E polymorphism: relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury." Epilepsy & behavior : E&B 2009 Nov; 16; 3; 501-6

  • D'Ambrosio R, Hakimian S, Stewart T, Verley DR, Fender JS, Eastman CL, Sheerin AH, Gupta P, Diaz-Arrastia R, Ojemann J, Miller JW "Functional definition of seizure provides new insight into post-traumatic epileptogenesis." Brain : a journal of neurology 2009 Oct; 132; Pt 10; 2805-21

  • Doherty MJ, Kim W, Youn CE, Haltiner AM, Oakley JC, Drane DL, Miller JW "Do atmospheric pressure changes influence seizure occurrence in the epilepsy monitoring unit?" Epilepsy & behavior : E&B 2009 Sep; 16; 1; 80-1

  • Miller JW "Of race, ethnicity, and rash: the genetics of antiepileptic drug-induced skin reactions." Epilepsy currents / American Epilepsy Society 2008 Sep-Oct ; 8; 5; 120-1

  • Drane DL, Ojemann GA, Aylward E, Ojemann JG, Johnson LC, Silbergeld DL, Miller JW, Tranel D "Category-specific naming and recognition deficits in temporal lobe epilepsy surgical patients." Neuropsychologia 2008 Apr; 46; 5; 1242-55

  • Miller JW, Gotman J "The meaning of interictal spikes in temporal lobe epilepsy: should we count them?" Neurology 2008 Aug; 71; 6; 392-3

  • Miller JW, D'Ambrosio R "When basic research doesn't translate to the bedside--lessons from the magnesium brain trauma study." Epilepsy currents / American Epilepsy Society 2007 Sep-Oct ; 7; 5; 133-5

  • Miller JW "Epilepsy surgery in the frontal lobe: terra incognita or new frontier?" Epilepsy currents / American Epilepsy Society 2007 Jul-Aug ; 7; 4; 98-9

  • Miller JW "Are ictal fast ripples an "electronic signature" for the seizure-onset zone?" Epilepsy currents / American Epilepsy Society 2007 Jan-Feb ; 7; 1; 7-9

  • Fu E, Chinowsky T, Nelson K, Johnston K, Edwards T, Helton K, Grow M, Miller JW, Yager P "SPR imaging-based salivary diagnostics system for the detection of small molecule analytes." Annals of the New York Academy of Sciences 2007 Mar; 1098; ; 335-44

  • Miller JW, Kim W, Holmes MD, Vanhatalo S "Ictal localization by source analysis of infraslow activity in DC-coupled scalp EEG recordings." NeuroImage 2007 Apr; 35; 2; 583-97

  • Miller KJ, Leuthardt EC, Schalk G, Rao RP, Anderson NR, Moran DW, Miller JW, Ojemann JG "Spectral changes in cortical surface potentials during motor movement." The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Feb; 27; 9; 2424-32

  • Miller JW, Anderson GD, Doherty MJ, Poolos NP "Position statement on the coverage of anticonvulsant drugs for the treatment of epilepsy: what's the problem with generic antiepileptic drugs? A call to action." Neurology 2007 Oct; 69; 18; 1806-8

  • Jung S, Jones TD, Sheerin AH, Miller JW, D'Ambrosio R, Anderson AE, Poolos NP "Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy." The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov; 27; 47; 13012-21

  • Miller KJ, denNijs M, Shenoy P, Miller JW, Rao RP, Ojemann JG "Real-time functional brain mapping using electrocorticography." NeuroImage 2007 Aug; 37; 2; 504-7

  • Hakimian S, Cheng-Hakimian A, Anderson GD, Miller JW "Rufinamide: a new anti-epileptic medication." Expert opinion on pharmacotherapy 2007 Aug; 8; 12; 1931-40

  • Miller JW "Long-term outcomes of childhood epilepsy: "the truth is rarely pure and never simple"." Epilepsy currents / American Epilepsy Society 2006 Nov-Dec ; 6; 6; 181-3

  • Mohutsky MA, Anderson GD, Miller JW, Elmer GW "Ginkgo biloba: evaluation of CYP2C9 drug interactions in vitro and in vivo." American journal of therapeutics 2006 Jan-Feb ; 13; 1; 24-31

  • Cheng-Hakimian A, Anderson GD, Miller JW "Rufinamide: Pharmacology, clinical trials, and role in clinical practice." International journal of clinical practice 2006 Nov; 60; 11; 1497-501

  • Drane DL, Williamson DJ, Stroup ES, Holmes MD, Jung M, Koerner E, Chaytor N, Wilensky AJ, Miller JW "Cognitive impairment is not equal in patients with epileptic and psychogenic nonepileptic seizures." Epilepsia 2006 Nov; 47; 11; 1879-86

  • D'Ambrosio R, Fender JS, Fairbanks JP, Simon EA, Born DE, Doyle DL, Miller JW "Progression from frontal-parietal to mesial-temporal epilepsy after fluid percussion injury in the rat." Brain : a journal of neurology 2005 Jan; 128; Pt 1; 174-88

  • Miller JW, Jayadev S, Dodrill CB, Ojemann GA "Gender differences in handedness and speech lateralization related to early neurologic insults." Neurology 2005 Dec; 65; 12; 1974-5

  • Chin PS, Miller JW "Ictal head version in generalized epilepsy." Neurology 2004 Jul; 63; 2; 370-2

  • Watson NF, Dodrill C, Farrell D, Holmes MD, Miller JW "Determination of language dominance with near-infrared spectroscopy: comparison with the intracarotid amobarbital procedure." Seizure : the journal of the British Epilepsy Association 2004 Sep; 13; 6; 399-402

  • D'Ambrosio R, Fairbanks JP, Fender JS, Born DE, Doyle DL, Miller JW "Post-traumatic epilepsy following fluid percussion injury in the rat." Brain : a journal of neurology 2004 Feb; 127; Pt 2; 304-14

  • Watson NF, Barber JK, Doherty MJ, Miller JW, Temkin NR "Does glucocorticoid administration prevent late seizures after head injury?" Epilepsia 2004 Jun; 45; 6; 690-4

  • Miller JW "Hippocampal sclerosis." Epilepsia 2004 Aug; 45; 8; 1005; author reply 1005

  • Doherty MJ, Jayadev S, Miller JW, Farrell DF, Holmes MD, Dodrill CB "Age at focal epilepsy onset varies by sex and hemispheric lateralization." Neurology 2003 May; 60; 9; 1473-7

  • Vanhatalo S, Holmes MD, Tallgren P, Voipio J, Kaila K, Miller JW "Very slow EEG responses lateralize temporal lobe seizures: an evaluation of non-invasive DC-EEG." Neurology 2003 Apr; 60; 7; 1098-104

  • Miller JW, Dodrill CB, Born DE, Ojemann GA "Atypical speech is rare in individuals with normal developmental histories." Neurology 2003 Mar; 60; 6; 1042-4

  • Hardy SG, Miller JW, Holmes MD, Born DE, Ojemann GA, Dodrill CB, Hallam DK "Factors predicting outcome of surgery for intractable epilepsy with pathologically verified mesial temporal sclerosis." Epilepsia 2003 Apr; 44; 4; 565-8

  • Doherty MJ, Simon E, De Menezes MS, Kuratani JD, Saneto RP, Homles MD, Farrell DF, Watson NF, Dodrill CB, Miller JW "When might hemispheric favouring of epileptiform discharges begin?" Seizure : the journal of the British Epilepsy Association 2003 Dec; 12; 8; 595-8

  • Holmes MD, Miller JW, Voipio J, Kaila K, Vanhatalo S "Vagal nerve stimulation induces intermittent hypocapnia." Epilepsia 2003 Dec; 44; 12; 1588-91

  • Vanhatalo S, Tallgren P, Becker C, Holmes MD, Miller JW, Kaila K, Voipio J "Scalp-recorded slow EEG responses generated in response to hemodynamic changes in the human brain." Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2003 Sep; 114; 9; 1744-54

  • Vanhatalo S, Voipio J, Dewaraja A, Holmes MD, Miller JW "Topography and elimination of slow EEG responses related to tongue movements." NeuroImage 2003 Oct; 20; 2; 1419-23

  • Doherty MJ, Walting PJ, Morita DC, Peterson RA, Miller JW, Holmes MD, Watson NF "Do nonspecific focal EEG slowing and epileptiform abnormalities favor one hemisphere?" Epilepsia 2002 Dec; 43; 12; 1593-5

  • Kelley WM, Ojemann JG, Wetzel RD, Derdeyn CP, Moran CJ, Cross DT, Dowling JL, Miller JW, Petersen SE "Wada testing reveals frontal lateralization for the memorization of words and faces." Journal of cognitive neuroscience 2002 Jan; 14; 1; 116-25

  • Duntley SP, Kim AH, Silbergeld DL, Miller JW "Characterization of the mu rhythm during rapid eye movement sleep." Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2001 Mar; 112; 3; 528-31

  • Holmes MD, Dodrill CB, Kutsy RL, Ojemann GA, Miller JW "Is the left cerebral hemisphere more prone to epileptogenesis than the right?" Epileptic disorders : international epilepsy journal with videotape 2001 Sep; 3; 3; 137-41

  • Holmes MD, Dodrill CB, Bachtler S, Wilensky AJ, Ojemann LM, Miller JW "Evidence That Emotional Maladjustment Is Worse in Men Than in Women with Psychogenic Nonepileptic Seizures." Epilepsy & behavior : E&B 2001 Dec; 2; 6; 568-573

  • Torack RM, Miller JW, Roth KA "Deafferentation-induced abnormal neurofilament phosphorylation in red nucleus neurones." Neuropathology and applied neurobiology 2001 Dec; 27; 6; 444-50

  • Torack RM, Roth KA, Miller JW "Neuronal argyrophilia and phosphorylated neurofilament accumulation secondary to deafferentation." Journal of neuropathology and experimental neurology 1996 Apr; 55; 4; 466-70

  • Ojemann JG, Miller JW, Silbergeld DL "Preserved function in brain invaded by tumor." Neurosurgery 1996 Aug; 39; 2; 253-8; discussion 258-9

  • Miller JW "Secondarily generalized seizures." Neurology 1995 Apr; 45; 4; 848; author reply 848-9

  • Torack RM, Miller JW "Denervation induced abnormal phosphorylation in hippocampal neurons." Brain research 1995 Jan; 669; 1; 135-9

  • Miller JW, Turner GM, Gray BC "Anticonvulsant effects of the experimental induction of hippocampal theta activity." Epilepsy research 1994 Jul; 18; 3; 195-204

  • Torack RM, Miller JW "Immunoreactive changes resulting from dopaminergic denervation of the dentate gyrus of the rat hippocampal formation." Neuroscience letters 1994 Mar; 169; 1-2; 9-12

  • Silbergeld DL, Miller JW "Resective surgery for medically intractable epilepsy associated with schizencephaly." Journal of neurosurgery 1994 May; 80; 5; 820-5

  • Miller JW, Gray BC, Turner GM "Role of the fastigial nucleus in generalized seizures as demonstrated by GABA agonist microinjections." Epilepsia 1993 Nov-Dec ; 34; 6; 973-8

  • Miller JW, Gray BC, Turner GM, Bardgett ME "An ascending seizure-controlling pathway in the medial brainstem and thalamus." Experimental neurology 1993 May; 121; 1; 106-12

  • Torack RM, Miller JW "Hippocampal pyramidal cell response to 6-hydroxydopamine lesions of the rat ventral tegmental area." Brain research 1992 Mar; 574; 1-2; 345-8

  • Miller JW "The role of mesencephalic and thalamic arousal systems in experimental seizures." Progress in neurobiology 1992 Aug; 39; 2; 155-78

  • Miller JW, Gray BC, Bardgett ME "Characterization of cholinergic regulation of seizures by the midline thalamus." Neuropharmacology 1992 Apr; 31; 4; 349-56

  • Miller JW, Gray BC, Bardgett ME "Effects of selective toxic lesions of cholinergic neurons of the laterodorsal tegmental nucleus on experimental seizures." Brain research 1992 May; 579; 1; 161-4

  • Miller JW, Turner DW, Pedersen ED "Trypsin, T. denticola and P. gingivalis levels as diagnostic markers for periodontitis." Northwestern dental research 1991 Fall; 3; 1; 12-4

  • Miller JW, Bardgett ME, Gray BC "The role of the laterodorsal tegmental nucleus of the rat in experimental seizures." Neuroscience 1991 ; 43; 1; 41-9

  • Green J, Morris JC, Sandson J, Miller JW "Progressive aphasia: a precursor of global dementia?" Neurology 1990 Mar; 40; 3 Pt 1; 423-9

  • Adams MD, Ralston WH, Miller JW, Ferrendelli JA "Electroencephalographic effects of intracisternally injected nonionic x-ray contrast media in rats." Investigative radiology 1990 Sep; 25 Suppl 1; ; S86-7

  • Miller JW, Ferrendelli JA "Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy." Annals of neurology 1990 Mar; 27; 3; 334-6

  • Miller JW, Ferrendelli JA "The central medial nucleus: thalamic site of seizure regulation." Brain research 1990 Feb; 508; 2; 297-300

  • Miller JW, Ferrendelli JA "Characterization of GABAergic seizure regulation in the midline thalamus." Neuropharmacology 1990 Jul; 29; 7; 649-55

  • Miller JW, Hall CM, Holland KD, Ferrendelli JA "Identification of a median thalamic system regulating seizures and arousal." Epilepsia 1989 Jul-Aug ; 30; 4; 493-500

  • Miller JW, McKeon AC, Ferrendelli JA "Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brainstem." Annals of neurology 1987 Nov; 22; 5; 615-21

  • Miller JW, Yanagihara T, Petersen RC, Klass DW "Transient global amnesia and epilepsy. Electroencephalographic distinction." Archives of neurology 1987 Jun; 44; 6; 629-33

  • Miller JW, Petersen RC, Metter EJ, Millikan CH, Yanagihara T "Transient global amnesia: clinical characteristics and prognosis." Neurology 1987 May; 37; 5; 733-7


Naomi Chaytor, Ph.D. Neuropsychologist
chaytor
Naomi Chaytor, Ph.D. received her doctorate in clinical psychology from Washington State University. She completed a neuropsychology internship at the Baylor Comprehensive Epilepsy Center in Houston, TX and a post-doctoral fellowship in Rehabilitation and Neuropsychology at UW School of Medicine. She is board certified in Clinical Neuropsychology by the American Board of Professional Psychology. Research interests include investigating the real-world impact of cognitive change after epilepsy surgery, the relationship between neuropsychological tests and everyday functioning, and the assessment of executive functions in epilepsy. Dr. Chaytor is Assistant Professor of Neurology and Director of the Regional Epilepsy Center Clinical Neuropsychology Laboratory.
Location
Neuropsychological Assessment Services at Harborview
Harborview Medical Center
325 Ninth Ave.
Seattle, WA 98104
206.744.3576
Selected Publications
  • Fraser RT, Johnson EK, Miller JW, Temkin N, Barber J, Caylor L, Ciechanowski P, Chaytor N "Managing epilepsy well: self-management needs assessment." Epilepsy & behavior : E&B 2011 Feb; 20; 2; 291-8

  • Chaytor N, Ciechanowski P, Miller JW, Fraser R, Russo J, Unutzer J, Gilliam F "Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy." Epilepsy & behavior : E&B 2011 Mar; 20; 3; 545-9

  • Thompson AW, Hantke N, Phatak V, Chaytor N "The Personality Assessment Inventory as a tool for diagnosing psychogenic nonepileptic seizures." Epilepsia 2010 Jan; 51; 1; 161-4

  • Ciechanowski P, Chaytor N, Miller J, Fraser R, Russo J, Unutzer J, Gilliam F "PEARLS depression treatment for individuals with epilepsy: a randomized controlled trial." Epilepsy & behavior : E&B 2010 Nov; 19; 3; 225-31

  • Hoskins LL, Binder LM, Chaytor NS, Williamson DJ, Drane DL "Comparison of oral and computerized versions of the word memory test." Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2010 Nov; 25; 7; 591-600

  • Thompson AW, Miller JW, Katon W, Chaytor N, Ciechanowski P "Sociodemographic and clinical factors associated with depression in epilepsy." Epilepsy & behavior : E&B 2009 Apr; 14; 4; 655-60

  • Russell H, Coady EL, Chaytor N "The impact of seizure-related items and comorbid medical conditions on the MMPI-2 profiles of patients with epilepsy and psychogenic nonepileptic seizures." Epilepsy & behavior : E&B 2009 Jul; 15; 3; 325-9

  • Chaytor N, Temkin N, Machamer J, Dikmen S "The ecological validity of neuropsychological assessment and the role of depressive symptoms in moderate to severe traumatic brain injury." Journal of the International Neuropsychological Society : JINS 2007 May; 13; 3; 377-85

  • Chaytor N, Schmitter-Edgecombe M "Fractionation of the dysexecutive syndrome in a heterogeneous neurological sample: comparing the Dysexecutive Questionnaire and the Brock Adaptive Functioning Questionnaire." Brain injury : [BI] 2007 Jun; 21; 6; 615-21

  • Chaytor N, Schmitter-Edgecombe M, Burr R "Improving the ecological validity of executive functioning assessment." Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2006 Apr; 21; 3; 217-27

  • Drane DL, Williamson DJ, Stroup ES, Holmes MD, Jung M, Koerner E, Chaytor N, Wilensky AJ, Miller JW "Cognitive impairment is not equal in patients with epileptic and psychogenic nonepileptic seizures." Epilepsia 2006 Nov; 47; 11; 1879-86

  • Chaytor N, Schmitter-Edgecombe M "Working memory and aging: a cross-sectional and longitudinal analysis using a self-ordered pointing task." Journal of the International Neuropsychological Society : JINS 2004 Jul; 10; 4; 489-503

  • Schmitter-Edgecombe M, Chaytor NS "Self-ordered pointing performance following severe closed-head injury." Journal of clinical and experimental neuropsychology 2003 Oct; 25; 7; 918-32

  • Chaytor N, Schmitter-Edgecombe M "The ecological validity of neuropsychological tests: a review of the literature on everyday cognitive skills." Neuropsychology review 2003 Dec; 13; 4; 181-97


Raimondo D'Ambrosio, Ph.D. Neurosurgery Research
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Raimondo D'Ambrosio, Ph.D. received his BS and Ph.D. in physiology from the University of Milan before serving as a postdoctoral fellow in neurophysiology at the University of Washington. He is an Associate Professor in the Department of Neurosurgery and the Regional Epilepsy Center and an adjunct in the Department of Neurology. His research interests include the physiology of glial cells and their role in epilepsy, and models of post-traumatic epilepsy. He is a member of the editorial board of Epilepsy Currents and a member of the publications committee of the American Epilepsy Society.
Location
Harborview Medical Center
325 Ninth Avenue
Box 359914
Seattle, Washington 98104-2499
Selected Publications
  • Eastman CL, Verley DR, Fender JS, Stewart TH, Nov E, Curia G, and D'Ambrosio R. Antiepileptic and Antiepileptogenic Performance of Carisbamate after Head Injury in The Rat: Blind and Randomized Studies. J Pharmacol Exp Ther. 2011 Mar;336(3):779-90.

  • Curia G, Levitt M, Fender JS, Miller JW, Ojemann J, D'Ambrosio R. Impact of injury location and severity on posttraumatic epilepsy in the rat: role of frontal neocortex. Cerebral Cortex. 2011; 21 (7): 1574-1592.

  • Stewart TH, Eastman CL, Groblewski PA, Fender JS, Verley DR, Cook DG, D'Ambrosio R. Chronic dysfunction of astrocytic inwardly rectifying K+ channels specific to the neocortical epileptic focus after fluid percussion injury in the rat. J Neurophysiol. 2010 Dec; 104(6):3345-60. Epub 2010 Sep 22

  • Eastman CL, Verley DR, Fender JS, Temkin NR and D'Ambrosio R. ECoG studies of valproate, carbamazepine and halothane in frontal lobe epilepsy induced by head injury in the rat . Experimental Neurology Exp Neurol. 2010, 224(2):369-88 (PubMed # 20420832 NIHMSID # 201020)

  • D'Ambrosio R, and Miller JW. What is an Epileptic Seizure? Unifying Definitions in Clinical Practice and Animal Research to Develop Novel Treatments. Epilepsy Currents, 2010, 10(3):61-66. review.

  • D'Ambrosio R, Hakimian, S, Stewart T, Verley DR, Fender JS, Eastman CL, Sheerin AH, Gupta P, Diaz-Arrastia R, Ojemann J, Miller JW. Functional Definition of Seizures Provides New Insights into Posttraumatic Epileptogenesis. Brain, 2009, 132(10):2805-2821. Cover article.

  • Janigro D., Gasparini S., D’Ambrosio R., McKhann G. and DiFrancesco D. (1997) Reduction of K+ uptake in glia prevents Long-Term Depression maintenance and causes epileptiform activity. Journal of Neuroscience, 17(8): 2813-24.

  • Gasparini S, Maccaferri G, D’Ambrosio R, and DiFrancesco D. (1996) The hyperpolarization-activated current (Ih/Iq) in rat hippocampal neurons. In: Neurobiology: Ionic Channels, Neurons and the brain, V. Torre and F. Conti eds., pp 63-74, Plenum Publishing Corporation.

  • McKhann G. II, D’Ambrosio R. and Janigro D. (1997) Heterogeneity of astrocyte resting membrane potentials and intracellular coupling revealed by whole cell and gramicidin-perforated patch recordings from cultured neocortical and hippocampal slice astrocytes. Journal of Neuroscience, 17(18): 6850-63.

  • D’Ambrosio R., Maris D.O., Grady M.S., Winn H.R. and Janigro D. (1998) Selective loss of Long-Term Potentiation, but not Depression, following fluid percussion injury. Brain Research, Vol. 786 (1-2) pp. 64-79.

  • D’Ambrosio R., Wenzel J., Schwartzkroin P.A., McKhann G. II and Janigro D. (1998) Functional specialization and topographic segregation of three types of hippocampal astrocytes. Journal of Neuroscience, 18(12):4425-38.

  • Hochman D.W., D’Ambrosio R., Janigro D., and Schwartzkroin P.A. (1999) Extracellular chloride and the maintenance of spontaneous epileptiform activity in rat hippocampal slices. Journal of Neurophysiology, 81:49-59.

  • Ngai A.C., Jolley M.A., D’Ambrosio R., Meno J.R. and Winn H.R. (1999) Frequency-dependent changes in cerebral blood flow and evoked potentials during somatosensory stimulation in the rat. Brain Research, 837:221-228.

  • D’Ambrosio R., Maris D.O., Grady S.M., Winn H.R., and Janigro D. (1999) Impaired K+ homeostasis and altered electrophysiological properties of post-traumatic hippocampal glia. Journal of Neuroscience, 19(18): 8152-62.

  • D’Ambrosio R., Gordon D.S., and Winn H.R. (2002) Differential roles of KIR channel and Na+/K+-pump in the regulation of extracellular K+ accumulation in rat hippocampus. Journal of Neurophysiology, Vol 87: 87-102.

  • D’Ambrosio R. (2002) The perforated patch technique. In: Neuromethods: Patch Clamp Applications and Protocols. Boulton AA, Baker GB, and Walz W eds. The Humana Press.

  • Iliff JJ, Ngai AC, D’Ambrosio R, and Winn HR (2003) Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex. American Journal of Physiology, 284(5):H1631-1637

  • D’Ambrosio R (2003) Basic science of posttraumatic epilepsy. In: Youman’s Neurological Surgery. 5th edition, pp2449-2460. Elsevier.

  • Meno JR, Higashi H, , Cambray AJ, Zhou J, D’Ambrosio R and Winn HR. Hippocampal injury and neurobehavioral deficits are improved by PD 81,723 following hyperglycemic cerebral ischemia. Experimental Neurology, (2003):183(1):188-96.

  • D’Ambrosio R, Fairbanks JP, Fender JS, Born DE, Doyle D and Miller JW. Posttraumatic epilepsy following fluid percussion injury in the rat. Brain 2004, 127(Pt 2):304-14. Epub 2003 Nov 7.

  • D’Ambrosio R. The role of glial ion channels in seizures and epileptogenesis. Pharmacology & Therapeutics, 2004, 03(2):95-108.

  • D’Ambrosio R. Progression of posttraumatic epilepsy following fluid percussion injury. In: Loscher W, Schmidt D (2004) New horizons in the development of antiepileptic drugs. Epilepsy Research, 60(2-3):77-159.

  • D’Ambrosio R and Perucca E. Epilepsy after head injury. Current Opinion in Neurology, 2004, 17(6):731-735.

  • D’Ambrosio R, Fender JS, Fairbanks JP, Simon E, Born DE, Doyle D, Miller JW. Progression from frontal-parietal to mesial-temporal epilepsy after fluid percussion injury in the rat. Brain 2005, 128(Pt 1):174-88. Epub 2004 Nov 24.

  • D'Ambrosio R. A possible causative role for blood brain barrier failure and reactive astrocytosys in acquired epilepsy. Epilepsy Currents, 2005, 5(6):244-6.

  • D'Ambrosio R (2006) Does glutamate released by astrocytes cause focal epilepsy? Epilepsy Currents, 6(5):12-15.

  • Miller JW and D'Ambrosio R (2007) When Basic Research Doesn’t Translate to the Bedside—Lessons from the Magnesium Brain Trauma Study. Epilepsy Currents, Epilepsy Curr. 2007 Sep-Oct;7(5):133-5.

  • Jung S, Jones TD, Lugo JN Jr, Sheerin AH, Miller JW, D'Ambrosio R, Anderson AE, Poolos NP. Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.J Neurosci. 2007 Nov 21;27(47):13012-21.


Robert T. Fraser, Ph.D. Rehabilitation Psychologist
fraser
Robert T. Fraser, Ph.D. is a licensed counseling and rehabilitation psychologist and Professor of Neurology, Neurological Surgery, and Rehabilitation Medicine at the University of Washington. Known for his pioneering work in the field of epilepsy rehabilitation counseling, Dr. Fraser has published numerous articles and book chapters. He currently serves on the Seizure Re-Classification Task Force and the Commission on the Burden of Epilepsy for the International League Against Epilepsy. Dr. Fraser has published widely on the vocational aspects of epilepsy, rehabilitation counseling, and job placement for those with neurological disorders. A dynamic speaker, he has made presentations in Copenhagen, Buenos Aires, Toronto, Berlin, and all across the United States. He is a Fellow of the American Psychological Association and serves on the Board of the Epilepsy Association of Washington and the National Epilepsy Foundation Professional Advisory Board. He is chair of the Epilepsy and Employment Task Force of the American Epilepsy Society and the Epilepsy Foundation.
Location
Regional Epilepsy Center
4th Floor
Maleng Building

Harborview Medical Center
325 9th Avenue
Seattle, WA 98104
Selected Publications
  • Fraser RT, Johnson EK, Miller JW, Temkin N, Barber J, Caylor L, Ciechanowski P, Chaytor N "Managing epilepsy well: self-management needs assessment." Epilepsy & behavior : E&B 2011 Feb; 20; 2; 291-8

  • Bell KR, Brockway JA, Hart T, Whyte J, Sherer M, Fraser RT, Temkin NR, Dikmen SS "Scheduled telephone intervention for traumatic brain injury: a multicenter randomized controlled trial." Archives of physical medicine and rehabilitation 2011 Oct; 92; 10; 1552-60

  • Fraser RT, Johnson K, Hebert J, Ajzen I, Copeland J, Brown P, Chan F "Understanding employers' hiring intentions in relation to qualified workers with disabilities: preliminary findings." Journal of occupational rehabilitation 2010 Dec; 20; 4; 420-6

  • Bell KR, Hoffman JM, Temkin NR, Powell JM, Fraser RT, Esselman PC, Barber JK, Dikmen S "The effect of telephone counselling on reducing post-traumatic symptoms after mild traumatic brain injury: a randomised trial." Journal of neurology, neurosurgery, and psychiatry 2008 Nov; 79; 11; 1275-81

  • Doctor JN, Castro J, Temkin NR, Fraser RT, Machamer JE, Dikmen SS "Workers' risk of unemployment after traumatic brain injury: a normed comparison." Journal of the International Neuropsychological Society : JINS 2005 Oct; 11; 6; 747-52

  • Bell KR, Temkin NR, Esselman PC, Doctor JN, Bombardier CH, Fraser RT, Hoffman JM, Powell JM, Dikmen S "The effect of a scheduled telephone intervention on outcome after moderate to severe traumatic brain injury: a randomized trial." Archives of physical medicine and rehabilitation 2005 May; 86; 5; 851-6

  • Johnson KL, Fraser RT "Mitigating the impact of multiple sclerosis on employment." Physical medicine and rehabilitation clinics of North America 2005 May; 16; 2; 571-82, x-xi

  • Fraser RT, Johnson EK, Clemmons DC, Getter A, Johnson KL, Gibbons L "Vocational rehabilitation in multiple sclerosis (MS): a profile of clients seeking services." Work (Reading, Mass.) 2003 ; 21; 1; 69-76

  • Dikmen SS, Temkin NR, Machamer JE, Holubkov AL, Fraser RT, Winn HR "Employment following traumatic head injuries." Archives of neurology 1994 Feb; 51; 2; 177-86

  • Batzel LW, Fraser RT "Resection surgery for epilepsy. Outcome and quality of life." Neurosurgery clinics of North America 1993 Apr; 4; 2; 345-51

  • Fraser RT "Improving functional rehabilitation outcome following epilepsy surgery." Acta neurologica Scandinavica. Supplementum 1988 ; 117; ; 122-8


Shahin Hakimian, M.D., M.A. Neurologist
hakimian
Shahin Hakimian, M.D., M.A. obtained his medical and masters degrees from Washington University in St. Louis in 2000. He completed residency training in neurology at Barnes-Jewish Hospital/Washington University in 2005. Dr. Hakimian then joined the epilepsy program as a senior fellow in epilepsy and clinical neurophysiology. Currently he is Acting Assistant Professor of Neurology at University of Washington and a member of the Regional Epilepsy Center. In addition to clinical epilepsy, he has interests in systems neurobiology, computational methods for analysis of biological signals, and quantitative methods of EEG analysis. He is board certified in neurology with an added qualification in clinical neurophysiology.
Location
Regional Epilepsy Center
4th Floor
Maleng Building

Harborview Medical Center
325 9th Avenue
Seattle, WA 98104
Selected Publications
  • Hakimian S, Kershenovich A, Miller JW, Ojemann JG, Hebb AO, D'Ambrosio R, Ojemann GA "Long-term outcome of extratemporal resection in posttraumatic epilepsy." Neurosurgical focus 2012 Mar; 32; 3; E10

  • Hakimian S, Miller JW "The genetics of antiepileptic drug-induced skin reactions." Clinical pharmacology and therapeutics 2011 Jun; 89; 6; 908-10

  • Holmes MD, Tucker DM, Quiring JM, Hakimian S, Miller JW, Ojemann JG "Comparing noninvasive dense array and intracranial electroencephalography for localization of seizures." Neurosurgery 2010 Feb; 66; 2; 354-62

  • D'Ambrosio R, Hakimian S, Stewart T, Verley DR, Fender JS, Eastman CL, Sheerin AH, Gupta P, Diaz-Arrastia R, Ojemann J, Miller JW "Functional definition of seizure provides new insight into post-traumatic epileptogenesis." Brain : a journal of neurology 2009 Oct; 132; Pt 10; 2805-21

  • Hakimian S, Norris SA, Greger B, Keating JG, Anderson CH, Thach WT "Time and frequency characteristics of Purkinje cell complex spikes in the awake monkey performing a nonperiodic task." Journal of neurophysiology 2008 Aug; 100; 2; 1032-40

  • Jensen MP, Hakimian S, Sherlin LH, Fregni F "New insights into neuromodulatory approaches for the treatment of pain." The journal of pain : official journal of the American Pain Society 2008 Mar; 9; 3; 193-9

  • Hakimian S, Cheng-Hakimian A, Anderson GD, Miller JW "Rufinamide: a new anti-epileptic medication." Expert opinion on pharmacotherapy 2007 Aug; 8; 12; 1931-40

  • Zackowski KM, Bastian AJ, Hakimian S, Mink JW, Perlmutter JS, Koller WC "Thalamic stimulation reduces essential tremor but not the delayed antagonist muscle timing." Neurology 2002 Feb; 58; 3; 402-10

  • Gierada DS, Hakimian S, Slone RM, Yusen RD "MR analysis of lung volume and thoracic dimensions in patients with emphysema before and after lung volume reduction surgery." AJR. American journal of roentgenology 1998 Mar; 170; 3; 707-14


Drury Hall, ARNP Nurse Practitioner
hall
Drury Hall, ARNP received his BSN and MSN from the University of Washington. Before joining the Epilepsy Center, he worked as an EMT and volunteered with the Peace Corps. He is an Advanced Registered Nurse Practitioner certified in acute care. At Harborview, he manages care for patients who have undergone neurosurgery or have been admitted for testing. His interests include the medical and surgical treatment of epilepsy and vagus nerve stimulation.
Location
Regional Epilepsy Center
4th Floor
Maleng Building

Harborview Medical Center
325 9th Avenue
Seattle, WA 98104
Selected Publications


Mark Holmes, M.D. Neurologist
holmes
Mark Holmes, M.D. completed his medical training at the Ohio State University of Medicine. He took his residency in neurology at Letterman Army Medical Center in San Francisco and was a fellow in epilepsy at the National Institutes of Health in Bethesda, Maryland. Dr. Holmes joined the staff of the Regional Epilepsy Center after four years in private practice in Boise, Idaho. He has directed the work of the EEG and Clinical Neurophysiology Lab at Harborview since 1992. Dr. Holmes is board-certified in neurology with an added qualification in clinical neurophysiology. He is Professor of Neurology at the University of Washington School of Medicine and has been elected to membership in the American Neurological Association.
Location
Regional Epilepsy Center
4th Floor
Maleng Building

Harborview Medical Center
325 9th Avenue
Seattle, WA 98104
Selected Publications
  • Ramon C, Holmes MD "Noninvasive epileptic seizure localization from stochastic behavior of short duration interictal high density scalp EEG data." Brain topography 2012 Jan; 25; 1; 106-15

  • Holmes MD, Quiring J, Tucker DM "Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networks." NeuroImage 2010 Jan; 49; 1; 80-93

  • Holmes MD, Tucker DM, Quiring JM, Hakimian S, Miller JW, Ojemann JG "Comparing noninvasive dense array and intracranial electroencephalography for localization of seizures." Neurosurgery 2010 Feb; 66; 2; 354-62

  • Holmes MD, Brown M, Tucker DM, Saneto RP, Miller KJ, Wig GS, Ojemann JG "Localization of extratemporal seizure with noninvasive dense-array EEG. Comparison with intracranial recordings." Pediatric neurosurgery 2008 ; 44; 6; 474-9

  • Thompson P, Rae J, Weber L, Pearson C, Goldeshtein Z, Holmes MD "Long-term seizure monitoring using a 256 contact dense array system." American journal of electroneurodiagnostic technology 2008 Jun; 48; 2; 93-106

  • Blakely T, Miller KJ, Rao RP, Holmes MD, Ojemann JG "Localization and classification of phonemes using high spatial resolution electrocorticography (ECoG) grids." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2008 ; 2008; ; 4964-7

  • Ramon C, Holmes MD, Freeman WJ, McElroy R, Rezvanian E "Comparative analysis of temporal dynamics of EEG and phase synchronization of EEG to localize epileptic sites from high density scalp EEG interictal recordings." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2008 ; 2008; ; 4548-50

  • Holmes MD "Dense array EEG: methodology and new hypothesis on epilepsy syndromes." Epilepsia 2008 ; 49 Suppl 3; ; 3-14

  • Souter MJ, Rozet I, Ojemann JG, Souter KJ, Holmes MD, Lee L, Lam AM "Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography." Journal of neurosurgical anesthesiology 2007 Jan; 19; 1; 38-44

  • Miller JW, Kim W, Holmes MD, Vanhatalo S "Ictal localization by source analysis of infraslow activity in DC-coupled scalp EEG recordings." NeuroImage 2007 Apr; 35; 2; 583-97

  • Koren MS, Holmes MD "Vagus nerve stimulation does not lead to significant changes in body weight in patients with epilepsy." Epilepsy & behavior : E&B 2006 Feb; 8; 1; 246-9

  • Zarkowski PA, Shin CJ, Holmes MD "Deblurring visual evoked potentials using commercially available software." Computer methods and programs in biomedicine 2006 Apr; 82; 1; 81-5

  • Drane DL, Williamson DJ, Stroup ES, Holmes MD, Jung M, Koerner E, Chaytor N, Wilensky AJ, Miller JW "Cognitive impairment is not equal in patients with epileptic and psychogenic nonepileptic seizures." Epilepsia 2006 Nov; 47; 11; 1879-86

  • Holmes MD, Sires BS "Flash visual evoked potentials predict visual outcome in traumatic optic neuropathy." Ophthalmic plastic and reconstructive surgery 2004 Sep; 20; 5; 342-6

  • Holmes MD, Brown M, Tucker DM "Are "generalized" seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence." Epilepsia 2004 Dec; 45; 12; 1568-79


Jeffrey G. Ojemann, M.D. Neurosurgeon
ojemann
Jeffrey G. Ojemann, M.D. received his medical degree from Washington University School of Medicine and completed his neurosurgery residency at Barnes-Jewish Hospital, both in St. Louis. He completed a pediatric neurosurgery fellowship at St. Louis Children’s hospital, as well as an epilepsy surgery fellowship at the University of Washington School of Medicine in Seattle. At UW, Dr. Ojemann is a Professor of Neurological Surgery with a particular interest in the surgical treatment of epilepsy and of tumors near brain tissue needed for thinking and speaking. He is also conducting research on electrical brain signals in memory and language, in part to find ways in which these signals can directly control computers. He is the son of Drs. George and Linda Ojemann, emeritus faculty members in neurological surgery.
Location
Neurological Surgery Clinic at Harborview
Ninth & Jefferson Building
5th Floor, Ninth & Jefferson Building
Box 359766
908 Jefferson St.
Seattle, WA 98104
206.744.9300
Selected Publications
  • Hakimian S, Kershenovich A, Miller JW, Ojemann JG, Hebb AO, D'Ambrosio R, Ojemann GA "Long-term outcome of extratemporal resection in posttraumatic epilepsy." Neurosurgical focus 2012 Mar; 32; 3; E10

  • Levitt MR, Niazi TN, Hopper RA, Ellenbogen RG, Ojemann JG "Resolution of syndromic craniosynostosis-associated Chiari malformation Type I without suboccipital decompression after posterior cranial vault release." Journal of neurosurgery. Pediatrics 2012 Feb; 9; 2; 111-5

  • Ishak GE, Poliakov AV, Poliachik SL, Saneto RP, McDaniel S, Ojemann JG, Shaw DW, Friedman SD "Tract-based spatial statistical analysis of diffusion tensor imaging in pediatric patients with mitochondrial disease: widespread reduction in fractional anisotropy of white matter tracts." AJNR. American journal of neuroradiology 2012 Oct; 33; 9; 1726-30

  • Miller KJ, Abel TJ, Hebb AO, Ojemann JG "Rapid online language mapping with electrocorticography." Journal of neurosurgery. Pediatrics 2011 May; 7; 5; 482-90

  • Miller KJ, Abel TJ, Hebb AO, Ojemann JG "Reorganization of large-scale physiology in hand motor cortex following hemispheric stroke." Neurology 2011 Mar; 76; 10; 927-9

  • Wray CD, Kraemer DL, Yang T, Poliachik SL, Ko AL, Poliakov A, Hebb AO, Novotny EJ, Ojemann JG "Freehand placement of depth electrodes using electromagnetic frameless stereotactic guidance." Journal of neurosurgery. Pediatrics 2011 Nov; 8; 5; 464-7

  • Miller KJ, Hermes D, Honey CJ, Sharma M, Rao RP, den Nijs M, Fetz EE, Sejnowski TJ, Hebb AO, Ojemann JG, Makeig S, Leuthardt EC "Dynamic modulation of local population activity by rhythm phase in human occipital cortex during a visual search task." Frontiers in human neuroscience 2010 ; 4; ; 197

  • Holmes MD, Tucker DM, Quiring JM, Hakimian S, Miller JW, Ojemann JG "Comparing noninvasive dense array and intracranial electroencephalography for localization of seizures." Neurosurgery 2010 Feb; 66; 2; 354-62

  • Levitt MR, Ojemann JG, Kuratani J "Insular epilepsy masquerading as multifocal cortical epilepsy as proven by depth electrode." Journal of neurosurgery. Pediatrics 2010 Apr; 5; 4; 365-7

  • Giussani C, Poliakov A, Ferri RT, Plawner LL, Browd SR, Shaw DW, Filardi TZ, Hoeppner C, Geyer JR, Olson JM, Douglas JG, Villavicencio EH, Ellenbogen RG, Ojemann JG "DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma." NeuroImage 2010 Aug; 52; 1; 217-23

  • Miller KJ, Schalk G, Fetz EE, den Nijs M, Ojemann JG, Rao RP "Cortical activity during motor execution, motor imagery, and imagery-based online feedback." Proceedings of the National Academy of Sciences of the United States of America 2010 Mar; 107; 9; 4430-5

  • Rowell J, Lynn AM, Filardi TZ, Celix J, Ojemann JG "Acute unilateral enlargement of the parotid gland immediately post craniotomy in a pediatric patient: a case report." Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2010 Sep; 26; 9; 1239-42

  • Miller KJ, Hebb AO, Hermes D, den Nijs M, Ojemann JG, Rao RN "Brain surface electrode co-registration using MRI and X-ray." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2010 ; 2010; ; 6015-8

  • Buzunov E, Ojemann JG, Robinson FR "Rhesus macaque as an animal model for posterior fossa syndrome following tumor resection." Pediatric neurosurgery 2010 Aug; 46; 2; 120-6

  • Yang T, Pruthi S, Geyer JR, Ojemann JG "MRI changes associated with vigabatrin treatment mimicking tumor progression." Pediatric blood & cancer 2010 Dec; 55; 6; 1221-3


Vaishali S. Phatak, Ph.D. Neuropsychologist
phatak
Vaishali S. Phatak, Ph.D. is a clinical neuropsychologist who is Acting Assistant Professor of Neurology at the University of Washington. She received her Ph.D. in clinical psychology from the University of Wisconsin-Milwaukee in 2005 and was a fellow in clinical neuropsychology at the Mayo Clinic from 2005 to 2007. Her interests include episodic and semantic memory performance in patients with temporal lobe epilepsy, epilepsy surgery, and counseling.
Location
Neuropsychological Assessment Services at Harborview
Harborview Medical Center
325 Ninth Ave.
Seattle, WA 98104
206.744.3576
Selected Publications
  • Malec, J.,Torsher, L., Dunn, W., Wiegmann, D., Arnold, J., Brown, D., Phatak,V. The Mayo High Performance Teamwork Scale (MHPTS): Reliability and Validity for Evaluating Key Crew Resource Management Skills. Simulation in Healthcare 2007 Spring; 2; 1; 4-10.

  • Phatak,V. & Tracy, T. Yoga101: Use of alternative therapies in traditional mental health settings. Nursing Matters 2003; 14; 12; 4-5.


Nicholas Poolos, M.D., Ph.D. Neurologist
poolos
Nicholas Poolos, M.D., Ph.D. received his medical degree and his Ph.D. in Neuroscience at Stanford University in 1991. After his neurology residency at Harvard Longwood Neurology Program, he participated in a postdoctoral fellowship in cellular neurophysiology at Baylor College of Medicine from 1996 to 1998. Before coming to Harborview in 2002, he was an instructor of neurology and neuroscience at Baylor. Dr. Poolos is board certified in neurology and is an Associate Professor of Neurology at the University of Washington School of Medicine. He has concentrated his research in cellular neurophysiology with an emphasis on cellular and molecular causes of epilepsy. Dr. Poolos is currently the Associate Director of the Regional Epilepsy Center and the chair of the Professional Advisory Board of the Epilepsy Foundation Northwest. He is on the editorial board of Epilepsy Currents.
Location
Regional Epilepsy Center
4th Floor
Maleng Building

Harborview Medical Center
325 9th Avenue
Seattle, WA 98104
Selected Publications
  • Poolos NP, Warner LN, Humphreys SZ, Williams S "Comparative efficacy of combination drug therapy in refractory epilepsy." Neurology 2012 Jan; 78; 1; 62-8

  • Jung S, Warner LN, Pitsch J, Becker AJ, Poolos NP "Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus." The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct; 31; 40; 14291-5

  • Jung S, Bullis JB, Lau IH, Jones TD, Warner LN, Poolos NP "Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling." The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 May; 30; 19; 6678-88

  • Jung S, Jones TD, Sheerin AH, Miller JW, D'Ambrosio R, Anderson AE, Poolos NP "Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy." The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov; 27; 47; 13012-21

  • Bullis JB, Jones TD, Poolos NP "Reversed somatodendritic I(h) gradient in a class of rat hippocampal neurons with pyramidal morphology." The Journal of physiology 2007 Mar; 579; Pt 2; 431-43

  • Poolos NP, Bullis JB, Roth MK "Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase." The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Jul; 26; 30; 7995-8003

  • Poolos NP "The h-channel: a potential channelopathy in epilepsy?" Epilepsy & behavior : E&B 2005 Aug; 7; 1; 51-6

  • Poolos NP, Jones TD "Patch-clamp recording from neuronal dendrites." Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2004 Nov; Chapter 6; ; Unit 6.19


Jeffrey J. Tsai, M.D., Ph.D. Neurologist
tsai
Jeffrey J. Tsai, M.D., Ph.D. obtained his medical degree and Ph.D. in neuroscience from Cornell University, where his doctoral research focused on depth perception. He completed a residency at the University of Colorado - Denver and a fellowship in clinical neurophysiology at the University of California - San Francisco. Before joining the Epilepsy Center, he served as a clinical scientist at the Smith-Kettlewell Eye Research Institute. He is Assistant Professor of Neurology at the University of Washington. His research focuses on neural circuit changes that lead to neural hyperexcitability. In addition to epilepsy, his interests include clinical neurophysiology, vision, audition, and computational biology.
Location
Regional Epilepsy Center
4th Floor
Maleng Building

Harborview Medical Center
325 9th Avenue
Seattle, WA 98104
Selected Publications
  • Tsai JJ, Wade AR, Norcia AM. Dynamics of normalization underlying masking in human visual cortex. J Neurosci. 2012 February, 32(8): 2783–2789.

  • Tsai JJ, Ales JM, Norcia AM, Wade, AR. Contrast gain control abnormalities in idiopathic generalized epilepsy. Ann Neurol. 2011 Oct, 70(4):574-82.

  • Tsai JJ, Koka K, Tollin DJ. Varying overall sound intensity to the two ears impacts interaural level difference discrimination thresholds by single neurons in the lateral superior olive. J Neurophysiol 2010 Feb;103(2):875-86.

  • Tollin DJ, Koka K, Tsai JJ. Interaural level difference discrimination thresholds for single neurons in the lateral superior olive. Journal of Neuroscience 2008; 28: 4848-60.

  • Tsai JJ, Victor JD. Binocular depth perception from unpaired image points need not depend on scene organization. Vision Research 2005, 45:527-32.

  • Tsai JJ, Victor JD. Reading a population code: a multi-scale neural model for representing binocular disparity. Vision Res. 2003, 43:445-66.

  • Tsai JJ, Victor JD. Neither occlusion constraint nor binocular disparity accounts for the perceived depth in the 'sieve effect'. Vision Res 2000, 40:2265-2276.


University of Washington Medical Center



Gail Anderson, Ph.D.
anderson
Gail Anderson, Ph.D. is a Professor of Pharmacy at the University of Washington. She received a BS in Pharmacy, an MS in Pharmacy Practice, and a PhD in Pharmaceutics from the University of Washington. Her research interests include treatment issues in patients with neurotrauma or epilepsy, drug interactions and pharmacokinetics in women and children, and drug interactions with alternative treatments.
Location
University of Washington Medical Center
H361A HSB
Box 357630
1959 NE Pacific St
Seattle WA 98195-7630
Selected Publications
  • Winn HR, Temkin NR, Anderson GD, Dikmen SS: Magnesium for neuroprotection after traumatic brain injury. Lancet Neurol. 2007 Jun;6(6):478-9.

  • Lynn AM, Bradford H, Kantor ED, Seng KY, Salinger DH, Chen J, Ellenbogen RG, Vicini P, Anderson GD: Postoperative ketorolac tromethamine use in infants aged 6-18 months: the effect on morphine usage, safety assessment, and stereo-specific pharmacokinetics. Anesth Analg. 2007 May;104(5):1040-51.

  • Anderson GD, Temkin NR, Awan AB, Winn HR: Effect of time, injury, age and ethanol on interpatient variability in valproic acid pharmacokinetics after traumatic brain injury. Clin Pharmacokinet. 2007;46(4):307-18.

  • Temkin NR, Anderson GD, Winn HR, Ellenbogen RG, Britz GW, Schuster J, Lucas T, Newell DW, Mansfield PN, Machamer JE, Barber J, Dikmen SS: Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol. 2007 Jan;6(1):29-38.

  • Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J: Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.

  • Mohutsky MA, Anderson GD, Miller JW, Elmer GW: Ginkgo biloba: evaluation of CYP2C9 drug interactions in vitro and in vivo. Am J Ther. 2006 Jan-Feb;13(1):24-31.

  • Anderson GD, Elmer GW, Kantor ED, Templeton IE, Vitiello MV: Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. Phytother Res. 2005 Sep;19(9):801-3.

  • Szot P, White SS, Shen DD, Anderson GD: Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expression. Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):285-9.

  • Anderson GD, Temkin NR, Chandler WL, Winn HR: Effect of valproate on hemostatic function in patients with traumatic brain injury. Epilepsy Res. 2003 Dec;57(2-3):111-9.

  • Donevan SD, White HS, Anderson GD, Rho JM: Voltage-dependent block of N-methyl-D-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-beta-hydroxybutyrate. Epilepsia. 2003 Oct;44(10):1274-9.

  • Hakimian S, Cheng-Hakimian A, Anderson GD, Miller JW: Rufinamide: a new anti-epileptic medication. Expert Opin Pharmacother. 2007 Aug;8(12):1931-40.

  • Anderson GD: Using pharmacokinetics to predict the effects of pregnancy and maternal-infant transfer of drugs during lactation. Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):947-60.

  • Cheng-Hakimian A, Anderson GD, Miller JW: Rufinamide: Pharmacology, clinical trials, and role in clinical practice. Int J Clin Pract. 2006 Nov;60(11):1497-501.

  • Li M, Anderson GD, Wang J: Drug-drug interactions involving membrane transporters in the human kidney. Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):505-32.

  • Anderson GD: Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet. 2005;44(10):989-1008.

  • Anderson GD: Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics. J Womens Health (Larchmt). 2005 Jan-Feb;14(1):19-29.

  • Anderson GD, Odegard PS: Pharmacokinetics of estrogen and progesterone in chronic kidney disease. Adv Chronic Kidney Dis. 2004 Oct;11(4):357-60.

  • Anderson GD: Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugs. Neurology. 2004 Nov 23;63(10 Suppl 4):S3-8.


Andrea Cheng-Hakimian, M.D. Neurologist
cheng-hakimian
Andrea Cheng-Hakimian, M.D. received her undergraduate degree from Harvard University and her medical degree from Washington University in Saint Louis. She completed her internship and residency in neurology at Barnes-Jewish Hospital/Washington University. She then completed two years of fellowship training in epilepsy and neurophysiology at Washington University in Saint Louis and the University of Washington. She is Acting Assistant Professor of Neurology at the University of Washington. As well as her general epilepsy clinic, Dr. Cheng- Hakimian attends at a specialty clinic caring for women with epilepsy during their pregnancies. Her research focuses on women's health and epilepsy, with a special emphasis on pregnancy and epilepsy.
Location
Neurology Clinic at UWMC
University of Washington Medical Center
8th Floor, 8 South
Box 356169
1959 N.E. Pacific St.
Seattle, WA 98195
Selected Publications
  • Hakimian S, Cheng-Hakimian A, Andersron GD, Miller JW. Rufinamide, a New Antiepileptic Medication. Expert Opinion on Pharmacotherapy 2007 Aug; 8(12) 1931-1940.

  • Cheng-Hakimian A, Anderson GD, Miller JW. Rufinamide: Pharmacology, Clinical Trials, and Role in Clinical Practice. Int J Clin Pract 2006 Nov; 60(11) 1497-1501.

  • Cheng-Hakimian A, Wilensky A. Limitations of Ictal Semiology for Lateralizing Seizures. In Epilepsy Surgery: Principles and Controversies. In Miller JW, Silbergeld DL (eds) Epilepsy Surgery: Principles and Controversies. New York: Informa, 2006.


John C. Oakley, M.D., Ph.D. Neurologist
oakley
John C. Oakley, M.D., Ph.D. graduated from the Medical Scientist Training Program at the University of Washington in 2001. His doctoral work focused on cellular neurophysiology. He completed a neurology residency at the University of Washington in 2005 and then joined the epilepsy program as a senior fellow in epilepsy and clinical neurophysiology. He is Acting Assistant Professor of Neurology at the University of Washington. His interests are in the basic mechanisms of epilepsy, inherited epilepsies, evoked potentials and EEG, operative neuro-monitoring, and autonomic nervous system testing.
Location
Neurology Clinic at UWMC
University of Washington Medical Center
8th Floor, 8 South
Box 356169
1959 N.E. Pacific St.
Seattle, WA 98195
Selected Publications
  • Oakley JC, Kalume F, Catterall WA "Insights into pathophysiology and therapy from a mouse model of Dravet syndrome." Epilepsia 2011 Apr; 52 Suppl 2; ; 59-61

  • Catterall WA, Kalume F, Oakley JC "NaV1.1 channels and epilepsy." The Journal of physiology 2010 Jun; 588; Pt 11; 1849-59

  • Oakley JC, Kalume F, Yu FH, Scheuer T, Catterall WA "Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy." Proceedings of the National Academy of Sciences of the United States of America 2009 Mar; 106; 10; 3994-9

  • Weiss MD, Oakley JC, Meekins GD "Hypoglossal neuropathy in Lewis-Sumner syndrome masquerading as motor neuron disease." Neurology 2006 Jul; 67; 1; 175-6

  • Crill WE, Schwindt PC, Oakley JC "Enhanced transmission of glutamate current flowing from the dendrite to the soma in rat neocortical layer 5 neurons." Novartis Foundation symposium 2002 ; 241; ; 61-8; discussion 68-71, 226-32

  • Oakley JC, Schwindt PC, Crill WE "Initiation and propagation of regenerative Ca(2+)-dependent potentials in dendrites of layer 5 pyramidal neurons." Journal of neurophysiology 2001 Jul; 86; 1; 503-13

  • Oakley JC, Schwindt PC, Crill WE "Dendritic calcium spikes in layer 5 pyramidal neurons amplify and limit transmission of ligand-gated dendritic current to soma." Journal of neurophysiology 2001 Jul; 86; 1; 514-27

  • Gordon SE, Oakley JC, Varnum MD, Zagotta WN "Altered ligand specificity by protonation in the ligand binding domain of cyclic nucleotide-gated channels." Biochemistry 1996 Apr; 35; 13; 3994-4001


Phillip Swanson, M.D., Ph.D. Neurologist
swanson
Phillip Swanson, M.D., Ph.D. obtained his medical degree from The Johns Hopkins University School of Medicine and his Ph.D. in biochemistry from the University of London. He completed a residency and fellowship in neurological medicine at Johns Hopkins. Dr. Swanson co-authored a neurology textbook and has published over 100 articles on neurological subjects. Besides epilepsy, his clinical and research interests include Parkinson's disease and stroke. Dr. Swanson is Professor of Neurology at the University of Washington School of Medicine and Adjunct Professor of Medicine in the Division of Gerontology and Geriatric Medicine. He directs the Neurology Residency Program at the University of Washington and is a widely respected consultant serving on a number of professional organization committees. He has been elected to the American Neurological Association and was voted one of the Best Doctors in America.
Location
Neurology Clinic at UWMC
University of Washington Medical Center
8th Floor, 8 South
Box 356169
1959 N.E. Pacific St.
Seattle, WA 98195
Selected Publications
  • Searles Nielsen S, Gallagher LG, Lundin JI, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H "Environmental tobacco smoke and Parkinson's disease." Movement disorders : official journal of the Movement Disorder Society 2012 Feb; 27; 2; 293-6

  • Firestone JA, Lundin JI, Powers KM, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H "Occupational factors and risk of Parkinson's disease: A population-based case-control study." American journal of industrial medicine 2010 Mar; 53; 3; 217-23

  • Powers KM, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H "Dietary fats, cholesterol and iron as risk factors for Parkinson's disease." Parkinsonism & related disorders 2009 Jan; 15; 1; 47-52

  • Costa-Mallen P, Checkoway H, Zabeti A, Edenfield MJ, Swanson PD, Franklin GM, Smith-Weller T, Sadrzadeh SM "The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease." American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008 Mar; 147B; 2; 216-22

  • Ton TG, Heckbert SR, Rossing MA, Kukull WA, Franklin GM, Swanson PD, Smith-Weller T, Checkoway H "Calcium channel blockers and beta-blockers in relation to Parkinson's disease." Parkinsonism & related disorders 2007 Apr; 13; 3; 165-9

  • Keene CD, Sonnen JA, Swanson PD, Kopyov O, Leverenz JB, Bird TD, Montine TJ "Neural transplantation in Huntington disease: long-term grafts in two patients." Neurology 2007 Jun; 68; 24; 2093-8

  • Kelada SN, Checkoway H, Kardia SL, Carlson CS, Costa-Mallen P, Eaton DL, Firestone J, Powers KM, Swanson PD, Franklin GM, Weller TS, Afsharinejad Z, Costa LG "5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study." Human molecular genetics 2006 Oct; 15; 20; 3055-62

  • Ton TG, Heckbert SR, Rossing MA, Kukull WA, Franklin GM, Swanson PD, Smith-Weller T, Checkoway H "Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease." Movement disorders : official journal of the Movement Disorder Society 2006 Jul; 21; 7; 964-9

  • Powers KM, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H "Diabetes, smoking, and other medical conditions in relation to Parkinson's disease risk." Parkinsonism & related disorders 2006 Apr; 12; 3; 185-9

  • Okada S, Farin FM, Stapleton P, Viernes H, Quigley SD, Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H "No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes." Neuroscience letters 2005 Mar; 375; 3; 178-80

  • Kelada SN, Costa-Mallen P, Checkoway H, Carlson CS, Weller TS, Swanson PD, Franklin GM, Afsharinejad Z, Costa LG "Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease." Pharmacogenetics and genomics 2005 Sep; 15; 9; 659-68

  • Swanson PD "Scanning speech and word history." Neurology 2005 Oct; 65; 8; 1328

  • Costa-Mallen P, Afsharinejad Z, Kelada SN, Costa LG, Franklin GM, Swanson PD, Viernes HM, Farin FM, Smith-Weller T, Checkoway H "DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls." Movement disorders : official journal of the Movement Disorder Society 2004 Jan; 19; 1; 76-83

  • Kelada SN, Stapleton PL, Farin FM, Bammler TK, Eaton DL, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H "Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease." Neuroscience letters 2003 Jan; 337; 1; 5-8

  • Powers KM, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H "Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes." Neurology 2003 Jun; 60; 11; 1761-6


Nancy Temkin, Ph.D.
temkin
Nancy Temkin, Ph.D. is Professor of Neurosurgery and Biostatistics at the University of Washington. She received a Ph.D. in statistics from the State University of New York at Buffalo in 1976. She was a visiting scientist at the Imperial Cancer Research Fund in London and an instructor of biometrics at the University of Colorado Medical Center in Denver. Her interests include clinical trials, recovery models, and traumatic brain injury. She received the Service Award of the American Epilepsy Society in 2003. She has been a member of the NIH/NINDS Clinical Trials Study Section and the CDC Working Group on Mild Traumatic Brain Injury.
Location
University of Washington
Office: F-646
Box 359924
1959 NE Pacific Street
Seattle, WA 98195
Tel: 206-616-6846
Selected Publications
  • Hypersomnia following traumatic brain injury. J Clin Sleep Med. 2007 Jun 15;3(4):363-8.
  • Powell JM, Temkin NR, Machamer JE, Dikmen SS: Gaining insight into patients' perspectives on participation in home management activities after traumatic brain injury. Am J Occup Ther. 2007 May-Jun;61(3):269-79.
  • Pagulayan KF, Temkin NR, Machamer JE, Dikmen SS: The measurement and magnitude of awareness difficulties after traumatic brain injury: a longitudinal study. J Int Neuropsychol Soc. 2007 Jul;13(4):561-70. Epub 2007
  • Winn HR, Temkin NR, Anderson GD, Dikmen SS: Magnesium for neuroprotection after traumatic brain injury. Lancet Neurol. 2007 Jun;6(6):478-9.
  • Wang MC, Temkin NR, Deyo RA, Jurkovich GJ, Barber J, Dikmen S: Timing of surgery after multisystem injury with traumatic brain injury: effect on neuropsychological and functional outcome. J Trauma. 2007 May;62(5):1250-8.
  • Chaytor N, Temkin N, Machamer J, Dikmen S: The ecological validity of neuropsychological assessment and the role of depressive symptoms in moderate to severe traumatic brain injury. J Int Neuropsychol Soc. 2007 May;13(3):377-85.
  • Anderson GD, Temkin NR, Awan AB, Winn HR: Effect of time, injury, age and ethanol on interpatient variability in valproic acid pharmacokinetics after traumatic brain injury. Clin Pharmacokinet. 2007;46(4):307-18.
  • Temkin NR, Anderson GD, Winn HR, Ellenbogen RG, Britz GW, Schuster J, Lucas T, Newell DW, Mansfield PN, Machamer JE, Barber J, Dikmen SS: Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol. 2007 Jan;6(1):29-38.
  • Bombardier CH, Fann JR, Temkin N, Esselman PC, Pelzer E, Keough M, Dikmen S: Posttraumatic stress disorder symptoms during the first six months after traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2006 Fall;18(4):501-8.
  • Tzortzidis F, Elahi F, Wright DC, Temkin N, Natarajan SK, Sekhar LN: Patient outcome at long-term follow-up after aggressive microsurgical resection of cranial base chondrosarcomas. Neurosurgery. 2006 Jun;58(6):1090-8.
  • Pagulayan KF, Temkin NR, Machamer J, Dikmen SS: A longitudinal study of health-related quality of life after traumatic brain injury. Arch Phys Med Rehabil. 2006 May;87(5):611-8.
  • Machamer J, Temkin N, Fraser R, Doctor JN, Dikmen S: Stability of employment after traumatic brain injury. J Int Neuropsychol Soc. 2005 Nov;11(7):807-16.
  • Hudak AM, Caesar RR, Frol AB, Krueger K, Harper CR, Temkin NR, Dikmen SS, Carlile M, Madden C, Diaz-Arrastia R: Functional outcome scales in traumatic brain injury: a comparison of the Glasgow Outcome Scale (Extended) and the Functional Status Examination. J Neurotrauma. 2005 Nov;22(11):1319-26.
  • Fann JR, Bombardier CH, Dikmen S, Esselman P, Warms CA, Pelzer E, Rau H, Temkin N: Validity of the Patient Health Questionnaire-9 in assessing depression following traumatic brain injury. J Head Trauma Rehabil. 2005 Nov-Dec;20(6):501-11.
  • Doctor JN, Castro J, Temkin NR, Fraser RT, Machamer JE, Dikmen SS: Workers' risk of unemployment after traumatic brain injury: a normed comparison. J Int Neuropsychol Soc. 2005 Oct;11(6):747-52.
  • Beghi E, Berg A, Carpio A, Forsgren L, Hesdorffer DC, Hauser WA, Malmgren K, Shinnar S, Temkin N, Thurman D, Tomson T: Comment on epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005 Oct;46(10):1698-9.
  • Bell KR, Temkin NR, Esselman PC, Doctor JN, Bombardier CH, Fraser RT, Hoffman JM, Powell JM, Dikmen S: The effect of a scheduled telephone intervention on outcome after moderate to severe traumatic brain injury: a randomized trial. Arch Phys Med Rehabil. 2005 May;86(5):851-6.
  • Temkin NR: Standard error in the Jacobson and Truax Reliable Change Index: the "classical approach" leads to poor estimates. J Int Neuropsychol Soc. 2004 Oct;10(6):899-901; discussion 902-3.
  • Dikmen SS, Bombardier CH, Machamer JE, Fann JR, Temkin NR: Natural history of depression in traumatic brain injury. Arch Phys Med Rehabil. 2004 Sep;85(9):1457-64.
  • Esselman PC, Dikmen SS, Bell K, Temkin NR. Access to inpatient rehabilitation after violence-related traumatic brain injury. Arch Phys Med Rehabil. 2004 Sep;85(9):1445-9.
  • Watson NF, Barber JK, Doherty MJ, Miller JW, Temkin NR: Does glucocorticoid administration prevent late seizures after head injury? Epilepsia. 2004 Jun;45(6):690-4.
  • Doctor JN, Bleichrodt H, Miyamoto J, Temkin NR, Dikmen S. A new and more robust test of QALYs. J Health Econ. 2004 Mar;23(2):353-67.
  • Anderson GD, Temkin NR, Chandler WL, Winn HR. Effect of valproate on hemostatic function in patients with traumatic brain injury. Epilepsy Res. 2003 Dec;57(2-3):111-9.
  • Bell KR, Esselman P, Garner MD, Doctor J, Bombardier C, Johnson K, Temkin N, Dikmen S: The use of a World Wide Web-based consultation site to provide support to telephone staff in a traumatic brain injury demonstration project.J Head Trauma Rehabil. 2003 Nov-Dec;18(6):504-11.


Children's Hospital



Neurologists
Edward J. (Rusty) Novotny, Jr., M.D.
Director, Epilepsy Program

John D. Kuratani, M.D.
Director, EEG Laboratory

Russell P. Saneto, D.O., Ph.D.
Neurologist
Neurosurgeons
Jeffrey G. Ojemann, M.D
Director, Epilepsy Surgery
Harborview biography
Neuropsychologists


appointment